Aphidicolin-resistant Mutants Of Mammalian Cells Often Have Alter- Ations In The Structure Of DNA Polymerase E That Render The Enzyme Insensitive To Inhibition. However, Some Mutants Show Alterations, Not In DNA Polymerase But In Ribonucleotide Reductase.

匿名用户 最后更新于 2021-12-01 19:35 化学类Chemistry

Aphidicolin-resistant mutants of mammalian cells often have alter- ations in the structure of DNA polymerase e that render the enzyme insensitive to inhibition. However, some mutants show alterations, not in DNA polymerase but in ribonucleotide reductase. How might a change in the latter enzyme cause an aphidicolin-resistant phenotype?

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