1 through 10 please im so confused 😭
Directions: Answer all question briefly on this worksheet. DO NOT erase the original problem numbers. You enrolled 6,500 men in 2005 and followed them for 10 years. Liver cancer is your outcome; none of the men had liver cancer at the start of the study. Of those men who drank alcohol daily (n=2,000) starting in 1990, 50 were diagnosed with liver cancer during the 10-year period. Of those who abstained from alcohol in 2005, 50 had liver cancer diagnosed during the 10-year period. Nobody died or was lost to follow up during the study period. 1. What is the research question in this study? 2. What type of study design is this, and how can you tell? Be specific 3. Complete the standard epidemiology table. Include the numbers and the proper headings. 2x2 table Total Total 4. Calculate the relative risk. Show formulas and work. 5. The p-value on your RR is p=0.03. Is your RR statistically significant? Explain how do you know? 6. Explain the meaning of the RR finding in a sentence. 7. You conducted additional studies with these men and found that the RR for those who drank one drink per day was 1.50 (95% CI:1.32-1.67) in comparison to the abstainers. For those men who drank three or more drinks per day the RR compared to the abstainers was 4.20 (95%CI 2.68-5.85). Which one of Hill's criteria does this illustrate? Explain. 8. You also conducted a review of the research literature and found that similar studies examining the relationship between alcohol consumption and liver cancer found the following: Smithson et al. RR 3.3 (95% CI:1.95-5.20) Ribera et al. RR 2.1 (95% CI:1.17-3.33) Gonzalez et al. RR 2.75 (95% CI 2.26-3.45) Which one of Hill's criteria does this illustrate? Explain. 9. Excluding those from #7 and #8, name 2 other criteria from Hill's list that we have already established? Explain. 10. Researchers are starting to feel pretty confident that daily alcohol consumption is CAUSALLY linked with liver cancer. What do you think is the one other Hill's criterion that researchers would like to have that would make them feel even more strongly about causality in this relationship?
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